Wilson, G.J., Marakalala, M.J., Hoving, J.C., Van Laarhoven, A., Drummond, R.A., Kerscher, B., Keeton, R., Van De Vosse, E., Ottenhoff, T.H.M., Plantinga, T.S., Alisjahbana, B., Govender, D., Besra, G.S., Netea, M.G., Reid, D.M., Willment, J.A., Jacobs, M., Yamasaki, S., Van Crevel, R., Brown, G.D. (2015) Frontiers in Cellular Neuroscience 9 MAY, 14. Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis. TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis. (2015) Immunology and Cell Biology 93(9):789-795.įrancisco, N.M., Hsu, N.-J., Keeton, R., Randall, P., Sebesho, B., Allie, N., Govender, D., Quesniaux, V., Ryffel, B., Kellaway, L., Jacobs, M. Mycobacterium tuberculosis infection of the 'non-classical immune cell'. Randall, P.J., Hsu, N.-J., Quesniaux, V., Ryffel, B., Jacobs, M. Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection. Segueni, N., Benmerzoug, S., Rose, S., Gauthier, A., Bourigault, M.-L., Reverchon, F., Philippeau, A., Erard, F., Le Bert, M., Bouscayrol, H., Wachter, T., Garcia, I., Kollias, G., Jacobs, M., Ryffel, B., Quesniaux, V.F.J.
TNFR1 and TNFR2 in protective immunity against M.Research projects include investigating immune responses during pulmonary tuberculosis and central nervous system tuberculosis, and investigating efficacy of anti-mycobacterial lead compounds and drug delivery systems. The group has significant skills and expertise in the application of in vitro cell culture and in vivo murine experimental models of tuberculosis, making extensive use of genetically modified mouse strains in which loss or gain of function studies can be performed. Research areas of interest include understanding basic mechanisms of host immune function against tuberculosis and the evaluation of anti-tuberculosis therapy and therapeutic approaches. The Experimental Tuberculosis and Immunology Research Group forms part of the Division of Immunology, which is jointly affiliated to the University of Cape Town and the National Health Laboratory Service. Selected publications | Contact details | Group members | Collaborationsįull Member, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, Faculty of Health Sciences, UCT NHLS Medical Scientist.
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